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Welcome to the Nucleic Acid Function and Technology Group headed by Professor Jørgen Kjems. We are located at the Department of Molecular Biology, Faculty of Science, Aarhus University, Denmark, and are associated with the following research centers: Interdisciplinary Nanoscience Center (iNANO) and Centre for DNA Nanotechnology (CDNA).

Welcome to the Nucleic Acid Function and Technology Group headed by Professor Jørgen Kjems. We are working with RNA and DNA biochemistry, chemical modification of nucleic acids, cell biology, delivery of oligonucleotides to cells and animal models, fluorescence microscopy, atomic force microscopy (AFM) of nucleic acids. We are located at the Department of Molecular Biology, Faculty of Science, Aarhus University, Denmark, and are associated with the following research centers: Interdisciplinary Nanoscience Center (iNANO) and Centre for DNA Nanotechnology (CDNA). The group is composed of three research laboratories described below:
 

Nucleic Acid Technology lab

The unique properties of DNA and RNA are used to construct novel molecular tools for bio-nanotechnology using e.g. the DNA origami technique or aptamer selection strategies. Computer-aided design, prediction and modeling are used intensively in developing new molecular functionality. Both designed or naturally occuring DNA or RNA structures are characterized by biochemical and biophysical methods.

Members:

 

RNA interference lab

The lab works with RNA interference as a tool and investigates the biology om microRNA regulation.

Members:

 

Drug delivery lab

The lab works on formulating nanoparticles to deliver nucleic acid drugs to cells.

Members:

 

 
 
 
 
     
     
 

RNAi highlights

The DNA 'origami' method was extended into 3D to create an addressable DNA box on the nanometre scale that can be opened by externally supplied DNA 'keys'. The study appeared online in Nature, May 6, 2009:
 
 

News

New single molecule study of hnRNP A1 interaction with telomere DNA G-quadruplex structures

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The DNA 'origami' method was extended into 3D to create an addressable DNA box on the nanometre scale that can be opened by externally supplied DNA 'keys'. The study appeared online at Nature, May 6, 2009: [Paper] [Podcast]
 

Kasper Jahn has won the EliteForsk travel award amounting to 250.000 DKK for his research on the application of DNA self-assembly chemistry for bringing together proteins and metal particles at the nano-scale.
Read the news here (in danish)
 
The SARSE - DNA origami package version 1.0 was released on the CDNA website (see intro page). The package makes it really easy to design complex DNA nanostructures. The package has a nice tutorial that goes through the steps involved in creating the logo of the University of Aarhus in DNA (see tutorial).
 

Ebbe S Andersen and colleagues introduce their ACS nano paper about a software program for designing DNA origami structures and the characterization of DNA dolphins with flexible tails. The full article may be found at this DOI.

 


 

 
 
 
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